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Peptide Hormone

Search Result - 1

HMRbase accession number	10288
Swiss-prot Accession number	Q5CZK2 (Sequence in FASTA format)
Description	Relaxin-3 precursor (Prorelaxin H3) [Contains: Relaxin-3 B chain;Relaxin-3 A chain].
Source organism	Pan troglodytes (Chimpanzee)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Pan.
Subcellular location	Secreted (By similarity)
Developmental Stage	N/A
Similarity	Belongs to the insulin family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 (GPCR135) and relaxin-3 receptor-2 (GPCR142)
Protein Length	142 Amino acids
Molecular weight	15348
References	1  PubMed abstract 16136131 2  PubMed abstract 15707501
Domain Name	Insulin
Hormone Name	Relaxin-3 B chain
Mature Hormone Sequence	RAAPYGVRLCGREFIRAVIFTCGGSRW
Position of mature hormone in Pre-Hormone protein	27 Residues from position (26-52)
Receptor	N/A
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments	!Receptor for this Hormone are either unknown or have not yet been curated

Search Result - 2

HMRbase accession number	10290
Swiss-prot Accession number	Q8HY17 (Sequence in FASTA format)
Description	Relaxin-3 precursor (Insulin-like peptide INSL7) (Insulin-like peptide7) [Contains: Relaxin-3 B chain; Relaxin-3 A chain].
Source organism	Sus scrofa (Pig)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;Sus.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the insulin family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 and relaxin-3 receptor-2
Protein Length	140 Amino acids
Molecular weight	15360
References	1  PubMed abstract 12686464 2  PubMed abstract 12506116 3  PubMed abstract 14522968
Domain Name	Insulin
Hormone Name	Relaxin-3 B chain
Mature Hormone Sequence	RASPYGVKLCGREFIRAVIFTCGGSRW
Position of mature hormone in Pre-Hormone protein	27 Residues from position (27-53)
Receptor	N/A
Gene ID	503836
PDB ID	N/A
Drugpedia	wiki
Comments	!Receptor for this Hormone are either unknown or have not yet been curated

Search Result - 3

HMRbase accession number	10332
Swiss-prot Accession number	Q8CHK2 (Sequence in FASTA format)
Description	Relaxin-3 precursor (Prorelaxin M3) (Insulin-like peptide INSL7)(Insulin-like peptide 7) [Contains: Relaxin-3 B chain; Relaxin-3 Achain].
Source organism	Mus musculus (Mouse)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the insulin family.
Tissue Specificity	High expression in the brain localized to the pons/medulla with highest levels in pars ventromedialis of the dorsal tegmental nucleus. Significant expression is also detected in the spleen, thymus, lung, testis and ovary
Post translational modification	N/A
Function	May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 and relaxin-3 receptor-2
Protein Length	141 Amino acids
Molecular weight	14926
References	1  PubMed abstract 12686464 2  PubMed abstract 11689565
Domain Name	Insulin
Hormone Name	Relaxin-3 B chain
Mature Hormone Sequence	RPAPYGVKLCGREFIRAVIFTCGGSRW
Position of mature hormone in Pre-Hormone protein	27 Residues from position (25-51)
Receptor	Q8BGE9   Detail in HMRbase    Q7TQP4   Detail in HMRbase    Q91ZZ5    Detail in HMRbase
Gene ID	212108
PDB ID	N/A
Drugpedia	wiki
Comments

Search Result - 4

HMRbase accession number	10338
Swiss-prot Accession number	Q8WXF3 (Sequence in FASTA format)
Description	Relaxin-3 precursor (Prorelaxin H3) (Insulin-like peptide INSL7)(Insulin-like peptide 7) [Contains: Relaxin-3 B chain; Relaxin-3 Achain].
Source organism	Homo sapiens (Human)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the insulin family.
Tissue Specificity	N/A
Post translational modification	N/A
Function	May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 (GPCR135) and relaxin-3 receptor-2 (GPCR142).
Protein Length	142 Amino acids
Molecular weight	15451
References	1   Holloway J.L., Lok S., Jaspers S.R.; "Homo sapiens insulin homolog polypeptide."; Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases. 2  PubMed abstract 12686464 3  PubMed abstract 12975309 4  PubMed abstract 12506116 5  PubMed abstract 14522968 6  PubMed abstract 14522967
Domain Name	N/A
Hormone Name	Relaxin-3 B chain
Mature Hormone Sequence	RAAPYGVRLCGREFIRAVIFTCGGSRW
Position of mature hormone in Pre-Hormone protein	27 Residues from position (26-52)
Receptor	Q9NSD7   Detail in HMRbase    Q8TDU9   Detail in HMRbase    Q9HBX9   Detail in HMRbase    Q8WXD0    Detail in HMRbase
Gene ID	117579
PDB ID	2FHW
Drugpedia	wiki
Comments

Search Result - 5

HMRbase accession number	10513
Swiss-prot Accession number	Q8BFS3 (Sequence in FASTA format)
Description	Relaxin-3 precursor (Prorelaxin R3) (Insulin-like peptide INSL7)(Insulin-like peptide 7) [Contains: Relaxin-3 B chain; Relaxin-3 Achain].
Source organism	Rattus norvegicus (Rat)
Taxonomical Classification	Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	Belongs to the insulin family.
Tissue Specificity	Highly abundant expression is detected in neurons within the ventomedial dorsal tegmental nucleus and the laterally central gray alpha of the pons. Also detected at much lower levels within the hippocampus
Post translational modification	N/A
Function	May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 and relaxin-3 receptor-2
Protein Length	140 Amino acids
Molecular weight	14922
References	1  PubMed abstract 12354304 2  PubMed abstract 12686464
Domain Name	N/A
Hormone Name	Relaxin-3 B chain
Mature Hormone Sequence	RPAPYGVKLCGREFIRAVIFTCGGSRW
Position of mature hormone in Pre-Hormone protein	27 Residues from position (24-50)
Receptor	N/A
Gene ID	266997
PDB ID	N/A
Drugpedia	wiki
Comments	!Receptor for this Hormone are either unknown or have not yet been curated